I've been keeping Siren intermedia for a few years, and I'm going to get some S. lacertina tomorrow. I will reiterate what Snakeguy said- a secure lid is crucial. They need hides and cover to feel secure, but will spend a lot of time in the open, cruising all over the tank. I would consider a 75 gallon the minimum size for one S. lacertina for life. Gentle current is best.
Water params are not that important as long as they are stable. Ambient temp is fine; if you want to breed them you'll probably need a cool-down period. I have used various substrates and am now using sand. Sirens are gape-and-suck feeders and will inhale smaller substrate particles when feeding. I never had any issues with impaction when keeping them on gravel (they always managed to spit the gravel out), but it worried me so I switched to sand. Bare glass would be fine too.
They are not picky eaters. My guys love nightcrawlers and bloodworms, and will also eat pellets, flakes, live or thawed shrimp, live daphnia and scuds, etc. My lessers are very bad at catching fish (I kept them with bitesize killies for more than a year and never had any killies go missing), but I have heard of people giving feeder goldies to greater sirens so maybe they are more efficient. They would probably also take pieces of fish fillets.
I disagree with Snakeguy that they can't be kept with fish, but fish selection is crucial. You need peaceable fish that won't fit in the siren's mouth, pick at its gills, or steal its food. I have had luck with bluefin killifish, pirate perch, and blackstripe topminnows; on the other hand, Seminole killifish and mosquitofish proved too nippy. Greater sirens may be too big to work with these fish.