I've run large canisters in the past. Few months ago switched to a new setup with a sump. I don't think I'd run any tank over 75 gallons without a sump now. Maintenance is much easier, they are more customizable, can hide equipment in the sump rather than in the main tank, and increases volume of water to the system. Also, I went with a DC pump that uses about half the wattage my Eheim 2262 did, but has much higher turnover rate.