Because proteins collect as an almost invisible film on the waters surface, when run thru the weir of an overflow box, the cascade effect sometimes separates them from the air water interface as foam, or bubbles. This fractionation usually takes a lot more agitation than in an overflow box, and is a form of natural fractionation. But.....
These proteins can glom on to other chemical species is the tank, as suggested by you previously adding the overdose of copper, that may have precipitated.
When purposely run thru a fractionation unit its no surprise.


In spring after my ponds (that sat idle all winter) caused my factionators units to run overtime, and I let the foam drip on the ground, or in buckets.
Removing those proteins (foam) is a good idea.
It is one of the reasons it is always suggested to turn off fractionation units, when using meds like copper, because (similar to carbon) fractionation is very good at removing liquid metals, and proteins.