One thing to consider, and this might be wrong due to my inexperience with c2c overflows, but I don't see any way that you would be able to adjust the water height. One nice thing about the setup I have is that I can raise and lower the height of the overflows if I want/need to. If I had thought about it more earlier, I would have drilled the holes a few inches lower to have some more room to work with, but I'm happy with it as is.
I do think that c2c is a good option though. If it were me, I'd prefer to have the weir teeth cut into the back of the aquarium glass and then have the overflow box on the outside of the aquarium with three 1.5-2" bulkheads. I do like the idea of leaving 6" on each end for the return bulkheads though.