The sky's the limit when it comes to external overflow boxes on large tanks.
Here are the overflow boxes on a 4,000 tank install shown on MFK
http://www.monsterfishkeepers.com/forums/showthread.php?t=187624&page=2
(Tank and stand now owned by bigrich545)
http://www.monsterfishkeepers.com/fo...=362706&page=2
Here's the back side of my much smaller tank
Each overflow box has two 2" drain holes and four 1" return holes, including return holes back into the tank adjacent to the uptake grids. Wasn't expecting the extra bonus of eight return holes. Gives me more options for the eleven holes for 1 1/2" bulkheads on the top of the tank that I insisted I had to have

Of course, durso/bean animal plumbing are not an option with these return holes...I would have preferred 1 1/2" returns, but it's all good...
I'd say go with two external overflow boxes along the back. Even my 300 gallon tank has two (internal) overflow boxes.