As
Milingu
suggested, I would try to determine if it's a scratch or a crack. And if it's a scratch deep enough to determine this visually, then I would treat it as a crack.
If it was always there, I would empty the tank and not use it until that panel has been replaced. And if it is a new development since you set the tank up, I would empty
right now, not this weekend or next month or whenever I have time...but
right now. This only seems paranoid to people who have not experienced a catastrophic tank failure in a finished area of their homes. I have.
If it is on a tank in a basement fish room, i.e. not necessarily a display tank and not capable of wrecking your house, I might try repairing it by cutting an identical size piece of equally thick glass and then siliconing this directly over top of the cracked pane, effectively giving you a double thickness pane on that surface of the tank. I tried this once, and it held up for a couple of years, until I tore the tank down for other reasons. It looks terrible; mine was 24 x 24 inches, and the silicone was a thin layer over that entire area. But, it held water for a couple of years and might have lasted longer given the chance; it was more an experiment than anything else.