I would recommend being able to handle twice the flow that you actually plan on running. This way you can have backup flow capabilities, even if one of the overflows becomes clogged.
On my 220, I have three 1.5" overflows, and two 3/4" returns. My overflows can handle a total of about 3600gph, but I only run about 1,600gph. My overflows are setup herbie style in that I use a ball valve on two of them to reduce the flow so that they remain fully siphoned, which makes virtually no sound. I then have my third overflow up a little bit higher and it stays dry, unless one of the other two becomes clogged. The third drain, the emergency drain, is also left wide open for max flow capability.