Yes, it will help with removing solid waste, but that won't help much in regards to supplying fresh water (and minerals) to your fish, or reducing the dissolved organic compounds that build up between those water changes.
I have a 6ft 125 like
@Jexnell posted, with 3 AC 110's for filtration, with a single 13-14" cichlid in that tank. I still do weekly water changes in the 80-90% range. Extra filtration can help one stretch the filter cleaning out a bit, but not the water changes.
I agree, certainly not the best idea without a divider in place that only a smaller, female, can pss through.